Publications 2008 - 2022

 

Hermeling JC, Herholz M, Baumann L, Cores EC, Zečić A, Hoppe T, Riemer J, Trifunovic A. Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans. Redox Biol. 2022 Nov 19;58:102533. doi: 10.1016/j.redox.2022.102533. Epub ahead of print. PMID: 36442394.

 

Ravanelli S, Li Q, Annibal A, Trifunovic A, Antebi A, Hoppe T. Reprograming of proteasomal degradation by branched chain amino acid metabolism. Aging Cell. 2022 Sep 27:e13725. doi: 10.1111/acel.13725. Epub ahead of print. PMID: 36168305.

 

Salscheider SL, Gerlich S, Cabrera-Orefice A, Peker E, Rothemann RA, Murschall LM, Finger Y, Szczepanowska K, Ahmadi ZA, Guerrero-Castillo S, Erdogan A, Becker M, Ali M, Habich M, Petrungaro C, Burdina N, Schwarz G, Klußmann M, Neundorf I, Stroud DA, Ryan MT, Trifunovic A, Brandt U, Riemer J. (2022), AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5. EMBO J. 2022 Sep 1;41(17):e110784.

 

Croon M, Szczepanowska K, Popovic M, Lienkamp C, Senft K, Brandscheid CP, Bock T, Gnatzy-Feik L, Ashurov A, Acton RJ, Kaul H, Pujol C, Rosenkranz S, Krüger M, Trifunovic A. (2022), FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction. Sci Adv. 2022 Apr 8;8(14):eabn7105

 

Rumyantseva A, Popovic M, Trifunovic A. (2022), CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain. 2022 Mar 29;145(1):92-104

 

Hoehne MN, Jacobs LJHC, Lapacz KJ, Calabrese G, Murschall LM, Marker T, Kaul H, Trifunovic A, Morgan B, Fricker M, Belousov VV, Riemer J. (2022), Spatial and temporal control of mitochondrial H2 O2 release in intact human cells. EMBO J. 2022 Apr 4;41(7):e109169

 

Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA. (2022), Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Dec 7;33(12):2398-2414.e9

 

Jobava R, Mao Y, Guan BJ, Hu D, Krokowski D, Chen CW, Shu XE, Chukwurah E, Wu J, Gao Z, Zagore LL, Merrick WC, Trifunovic A, Hsieh AC, Valadkhan S, Zhang Y, Qi X, Jankowsky E, Topisirovic I, Licatalosi DD, Qian SB, Hatzoglou M. (2022), Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress. Mol Cell. 2021 Oct 21;81(20):4191-4208.e8

 

Pujol C, Legrand A, Parodi L, Thomas P, Mochel F, Saracino D, Coarelli G, Croon M, Popovic M, Valet M, Villain N, Elshafie S, Issa M, Zuily S, Renaud M, Marelli-Tosi C, Legendre M, Trimouille A, Kemlin I, Mathieu S, Gleeson JG, Lamari F, Galatolo D, Alkouri R, Tse C, Rodriguez D, Ewenczyk C, Fellmann F, Kuntzer T, Blond E, El Hachimi KH, Darios F, Seyer A, Gazi AD, Giavalisco P, Perin S, Boucher JL, Le Corre L, Santorelli FM, Goizet C, Zaki MS, Picaud S, Mourier A, Steculorum SM, Mignot C, Durr A, Trifunovic A, Stevanin G. (2022), Implication of folate deficiency in CYP2U1 loss of function. J Exp Med. 2021 Nov 1;218(11):e20210846

 

Bock T, Türk C, Aravamudhan S, Keufgens L, Bloch W, Rozsivalova DH, Romanello V, Nogara L, Blaauw B, Trifunovic A, Braun T, Krüger M. (2022), PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B. Nat Commun. 2021 Aug 12;12(1):4900

 

Calculli G, Lee HJ, Shen K, Pham U, Herholz M, Trifunovic A, Dillin A, Vilchez D. (2021) "Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans." Sci Adv. 2021 Jun 25;7(26):eabg3012.

 

Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A. (2021)  "Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR." Sci Adv. 2021 May 26;7(22):eabf0971

 

Szczepanowska K, Trifunovic A. (2021) "Mitochondrial matrix proteases: quality control and beyond. " FEBS J. 2021 May 10

 

Silva-Pinheiro P, Pardo-Hernández C, Reyes A, Tilokani L, Mishra A, Cerutti R, Li S, Rozsivalova DH, Valenzuela S, Dogan SA, Peter B, Fernández-Silva P, Trifunovic A, Prudent J, Minczuk M, Bindoff L, Macao B, Zeviani M, Falkenberg M, Viscomi C. (2021) "DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion. " Nucleic Acids Res. 2021 May 21;49(9):5230-5248.

 

Dinić M, Herholz M, Kačarević U, Radojević D, Novović K, Đokić J, Trifunović A, Golić N. (2021) "Host-commensal interaction promotes health and lifespan in Caenorhabditis elegans through the activation of HLH-30/TFEB-mediated autophagy. "Aging (Albany NY). 2021 Mar 26;13(6):8040-8054.

 

Aravamudhan S, Türk C, Bock T, Keufgens L, Nolte H, Lang F, Krishnan RK, König T, Hammerschmidt P, Schindler N, Brodesser S, Rozsivalova DH, Rugarli E, Trifunovic A, Brüning J, Langer T, Braun T, Krüger M. (2021) “Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein. J Mol Cell Cardiol. 2021 Feb 4.

 

Szczepanowska K, Trifunovic A.Biochim Biophys Acta Bioenerg. (2021), “Tune instead of destroy: How proteolysis keeps OXPHOS in shape”. Jan 6.

 

Hofsetz E, Huesgen PF, Trifunovic A.(2021), “Identification of Putative Mitochondrial Protease Substrates”. Methods Mol Biol. 2021.

 

Rumyantseva A, Motori E, Trifunovic A. (2020), “DARS2 is indispensable for Purkinje cell survival and protects against cerebellar ataxia”. Hum Mol Genet. 2020 Oct 10. 

 

Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M, Schumacher B (2020). “A C. elegans model for neurodegeneration in Cockayne syndrome”. Nucleic Acids Res. 2020 Oct 6.

 

Hofsetz E, Demir F, Szczepanowska K, Kukat A, Kizhakkedathu JN, Trifunovic A, Huesgen PF (2020). “The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis”. Mol Cell Proteomics. 2020 Aug;19(8).

 

Meul T, Berschneider K, Schmitt S, Mayr CH, Mattner LF, Schiller HB, Yazgili AS, Wang X, Lukas C, Schlesser C, Prehn C, Adamski J, Graf E, Schwarzmayr T, Perocchi F, Kukat A, Trifunovic A, Kremer L, Prokisch H, Popper B, von Toerne C, Hauck SM, Zischka H, Meiners S. (2020), “Mitochondrial Regulation of the 26S Proteasome”. Cell Rep. 2020 Aug 25;32(8).

 

Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC (2020). “GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function”. Cell Metab. 2020 Jun 2;31(6). 

 

Shytaj IL, Lucic B, Forcato M, Penzo C, Billingsley J, Laketa V, Bosinger S, Stanic M, Gregoretti F, Antonelli L, Oliva G, Frese CK, Trifunovic A, Galy B, Eibl C, Silvestri G, Bicciato S, Savarino A, Lusic M (2020). “Alterations of redox and iron metabolism accompany the development of HIV latency”. EMBO J. 2020 May 4;39(9).

  

Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A (2020). “A salvage pathway maintains highly functional respiratory complex I”. Nat Commun. 2020 Apr 2;11(1).

 

Nemeth CL, Tomlinson SN, Rosen M, O'Brien BM, Larraza O, Jain M, Murray CF, Marx JS, Delannoy M, Fine AS, Wu D, Trifunovic A, Fatemi A (2020). “Neuronal ablation of mt-AspRS in mice induces immune pathway activation prior to severe and progressive cortical and behavioral disruption”. Exp Neurol. 2020 Apr. 

 

Ricke KM, Paß T, Kimoloi S, Fährmann K, Jüngst C, Schauss A, Baris OR, Aradjanski M, Trifunovic A, Eriksson Faelker TM, Bergami M, Wiesner RJ (2020). “Mitochondrial dysfunction combined with high calcium load leads to impaired antioxidant defense underlying the selective loss of nigral dopaminergic neurons”. J Neurosci. 2020 Jan 29

 

Lee, H. J., A. Noormohammadi, S. Koyuncu, G. Calculli, M. S. Simic, M. Herholz, A. Trifunovic and D. Vilchez (2019). "Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans." Nat Metab 1(8): 790-810

 

Herholz, M., E. Cepeda, L. Baumann, A. Kukat, J. Hermeling, S. Maciej, K. Szczepanowska, V. Pavlenko, P. Frommolt and A. Trifunovic (2019). "KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants." Nat Commun 10(1): 3323

 

Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L. Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. EMBO Rep. 2019 Apr;20(4):e47407

 

Chouchani, E. T., M. Liesa and A. Trifunovic (2018). "Mechanisms of Mitochondria Assembly, Dynamics and Turnover in Health and Disease." J Mol Biol 430(24): 4821-4822.

 

Becker, C., A. Kukat, K. Szczepanowska, S. Hermans, K. Senft, C. P. Brandscheid, P. Maiti and A. Trifunovic (2018). "CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis." EMBO Rep 19(5).

 

Theisen, B. E., A. Rumyantseva, J. S. Cohen, W. A. Alcaraz, D. N. Shinde, S. Tang, S. Srivastava, J. Pevsner, A. Trifunovic and A. Fatemi (2017). "Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy." Am J Med Genet A 173(9): 2505-2510.

 

Szczepanowska, K. and A. Trifunovic (2017). "Origins of mtDNA mutations in ageing." Essays Biochem 61(3): 325-337.

 

Aradjanski, M., S. A. Dogan, S. Lotter, S. Wang, S. Hermans, R. Wibom, E. Rugarli and A. Trifunovic (2017). "DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells." Hum Mol Genet 26(21): 4181-4189.

 

Szczepanowska, K., P. Maiti, A. Kukat, E. Hofsetz, H. Nolte, K. Senft, C. Becker, B. Ruzzenente, H. T. Hornig-Do, R. Wibom, R. J. Wiesner, M. Kruger and A. Trifunovic (2016). "CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels." Embo Journal 35(23): 2566-2583.

 

Seiferling, D., K. Szczepanowska, C. Becker, K. Senft, S. Hermans, P. Maiti, T. Konig, A. Kukat and A. Trifunovic (2016). "Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt." Embo Reports 17(7): 953-964.

 

Islam, M. S., H. Nolte, W. Jacob, A. B. Ziegler, S. Putz, Y. Grosjean, K. Szczepanowska, A. Trifunovic, T. Braun, H. Heumann, R. Heumann, B. Hovemann, D. J. Moore and M. Kruger (2016). "Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease." Human Molecular Genetics 25(24): 5365-5382.

 

Guaras, A., E. Perales-Clemente, E. Calvo, R. Acin-Perez, M. Loureiro-Lopez, C. Pujol, I. Martinez-Carrascoso, E. Nunez, F. Garcia-Marques, M. A. Rodriguez-Hernandez, A. Cortes, F. Diaz, A. Perez-Martos, C. T. Moraes, P. Fernandez-Silva, A. Trifunovic, P. Navas, J. Vazquez and J. A. Enriquez (2016). "The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency." Cell Reports 15(1): 197-209.

 

Szczepanowska, K. and A. Trifunovic (2015). "Different faces of mitochondrial DNA mutators." Biochimica Et Biophysica Acta-Bioenergetics 1847(11): 1362-1372.

 

Rugarli, E. and A. Trifunovic (2015). "Is mitochondrial free radical theory of aging getting old?" Biochimica Et Biophysica Acta-Bioenergetics 1847(11): 1345-1346.

 

Papadopoulos, C., G. Orso, G. Mancuso, M. Herholz, S. Gumeni, N. Tadepalle, C. Jungst, A. Tzschichholz, A. Schauss, S. Honing, A. Trifunovic, A. Daga and E. I. Rugarli (2015). "Spastin Binds to Lipid Droplets and Affects Lipid Metabolism."Plos Genetics 11(4).

 

Belaidi, A. A., J. Roper, S. Arjune, S. Krizowski, A. Trifunovic and G. Schwarz (2015). "Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency." Biochemical Journal 469: 211-221.

 

Turpin, S. M., H. T. Nicholls, D. M. Willmes, A. Mourier, S. Brodesser, C. M. Wunderlich, J. Mauer, E. Xu, P. Hammerschmidt, H. S. Bronneke, A. Trifunovic, G. LoSasso, F. T. Wunderlich, J. W. Kornfeld, M. Bluher, M. Kroke and J. C. Bruing (2014). "Obesity-Induced CerS6-Dependent C-16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance." Cell Metabolism 20(4): 678-686.

 

Trifunovic, A. and N. Ventura (2014). "Mitochondria and metabolic control of the aging process." Experimental Gerontology 56: 1-2.

 

Li, L. S., A. Trifunovic, M. Kohler, Y. X. Wang, J. P. Berglund, C. Illies, L. Juntti-Berggren, N. G. Larsson and P. O. Berggren (2014). "Defects in beta-Cell Ca2+ Dynamics in Age-Induced Diabetes." Diabetes 63(12): 4100-4114.

 

Kukat, A., S. A. Dogan, D. Edgar, A. Mourier, C. Jacoby, P. Maiti, J. Mauer, C. Becker, K. Senft, R. Wibom, A. P. Kudin, K. Hultenby, U. Flogel, S. Rosenkranz, D. Ricquier, W. S. Kunz and A. Trifunovic (2014). "Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity." Plos Genetics 10(6).

 

Dogan, S. A., C. Pujol, P. Maiti, A. Kukat, S. Y. Wang, S. Hermans, K. Senft, R. Wibom, E. I. Rugarli and A. Trifunovic (2014). "Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart." Cell Metabolism 19(3): 458-469.

 

Coutelle, O., H. T. Hornig-Do, A. Witt, M. Andree, L. M. Schiffmann, M. Piekarek, K. Brinkmann, J. M. Seeger, M. Liwschitz, S. Miwa, M. Hallek, M. Kronke, A. Trifunovic, S. A. Eming, R. J. Wiesner, U. T. Hacker and H. Kashkar (2014). "Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing." Embo Molecular Medicine 6(5): 624-639.

 

Pujol, C., I. Bratic-Hench, M. Sumakovic, J. Hench, A. Mourier, L. Baumann, V. Pavlenko and A. Trifunovic (2013). "Succinate Dehydrogenase Upregulation Destabilize Complex I and Limits the Lifespan of gas-1 Mutant." Plos One 8(3).

 

Ahlqvist, K. J., R. H. Hamalainen, S. Yatsuga, M. Uutela, M. Terzioglu, A. Gotz, S. Forsstrom, P. Salven, A. Angers-Loustau, O. H. Kopra, H. Tyynismaa, N. G. Larsson, K. Wartiovaara, T. Prolla, A. Trifunovic and A. Suomalainen (2012). "Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice." Cell Metabolism 15(1): 100-109.

 

Kukat, A., D. Edgar, I. Bratic, P. Maiti and A. Trifunovic (2011). "Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts." Biochemical and Biophysical Research Communications 409(3): 394-399.

 

Hench, J., I. B. Hench, C. Pujol, S. Ipsen, S. Brodesser, A. Mourier, M. Tolnay, S. Frank and A. Trifunovic (2011). "A Tissue-Specific Approach to the Analysis of Metabolic Changes in Caenorhabditis elegans." Plos One 6(12).

 

Ross, J. M., J. Oberg, S. Brene, G. Coppotelli, M. Terzioglu, K. Pernold, M. Goiny, R. Sitnikov, J. Kehr, A. Trifunovic, N. G. Larsson, B. J. Hoffer and L. Olson (2010). "High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio." Proceedings of the National Academy of Sciences of the United States of America 107(46): 20087-20092.

 

Edgar, D., N. G. Larsson and A. Trifunovic (2010). "Point Mutations Are Causing Progeroid Phenotypes in the mtDNA Mutator Mouse." Cell Metabolism 11(1): 1-1.

 

Bruning, J., T. Langer and A. Trifunovic (2010). "Highlight: The Biology of Aging: Mechanisms and Intervention." Biological Chemistry 391(10): 1113-1113.

 

Bratic, I. and A. Trifunovic (2010). "Mitochondrial energy metabolism and ageing." Biochimica Et Biophysica Acta-Bioenergetics 1797(6-7): 961-967.

 

Bratic, I., J. Hench and A. Trifunovic (2010). "Caenorhabditis elegans as a model system for mtDNA replication defects." Methods 51(4): 437-443.

 

Edgar, D., I. Shabalina, Y. Camara, A. Wredenberg, M. A. Calvaruso, L. Nijtmans, J. Nedergaard, B. Cannon, N. G. Larsson and A. Trifunovic (2009). "Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice." Cell Metabolism 10(2): 131-138.

 

Bratic, I., J. Hench, J. Henriksson, A. Antebi, T. R. Burglin and A. Trifunovic (2009). "Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development." Nucleic Acids Research 37(6): 1817-1828.

 

Stewart, J. B., C. Freyer, J. L. Elson, A. Wredenberg, Z. Cansu, A. Trifunovic and N. G. Larsson (2008). "Strong purifying selection in transmission of mammalian mitochondrial DNA." Plos Biology 6(1): 63-71.