CECAD Microsite

Publications 2008 - 2019


Lee, H. J., A. Noormohammadi, S. Koyuncu, G. Calculli, M. S. Simic, M. Herholz, A. Trifunovic and D. Vilchez (2019). "Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans." Nat Metab 1(8): 790-810.


Herholz, M., E. Cepeda, L. Baumann, A. Kukat, J. Hermeling, S. Maciej, K. Szczepanowska, V. Pavlenko, P. Frommolt and A. Trifunovic (2019). "KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants." Nat Commun 10(1): 3323.


Chouchani, E. T., M. Liesa and A. Trifunovic (2018). "Mechanisms of Mitochondria Assembly, Dynamics and Turnover in Health and Disease." J Mol Biol 430(24): 4821-4822.


Becker, C., A. Kukat, K. Szczepanowska, S. Hermans, K. Senft, C. P. Brandscheid, P. Maiti and A. Trifunovic (2018). "CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis." EMBO Rep 19(5).


Theisen, B. E., A. Rumyantseva, J. S. Cohen, W. A. Alcaraz, D. N. Shinde, S. Tang, S. Srivastava, J. Pevsner, A. Trifunovic and A. Fatemi (2017). "Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy." Am J Med Genet A 173(9): 2505-2510.


Szczepanowska, K. and A. Trifunovic (2017). "Origins of mtDNA mutations in ageing." Essays Biochem 61(3): 325-337.


Aradjanski, M., S. A. Dogan, S. Lotter, S. Wang, S. Hermans, R. Wibom, E. Rugarli and A. Trifunovic (2017). "DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells." Hum Mol Genet 26(21): 4181-4189.


Szczepanowska, K., P. Maiti, A. Kukat, E. Hofsetz, H. Nolte, K. Senft, C. Becker, B. Ruzzenente, H. T. Hornig-Do, R. Wibom, R. J. Wiesner, M. Kruger and A. Trifunovic (2016). "CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels." Embo Journal 35(23): 2566-2583.


Seiferling, D., K. Szczepanowska, C. Becker, K. Senft, S. Hermans, P. Maiti, T. Konig, A. Kukat and A. Trifunovic (2016). "Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt." Embo Reports 17(7): 953-964.


Islam, M. S., H. Nolte, W. Jacob, A. B. Ziegler, S. Putz, Y. Grosjean, K. Szczepanowska, A. Trifunovic, T. Braun, H. Heumann, R. Heumann, B. Hovemann, D. J. Moore and M. Kruger (2016). "Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease." Human Molecular Genetics 25(24): 5365-5382.


Guaras, A., E. Perales-Clemente, E. Calvo, R. Acin-Perez, M. Loureiro-Lopez, C. Pujol, I. Martinez-Carrascoso, E. Nunez, F. Garcia-Marques, M. A. Rodriguez-Hernandez, A. Cortes, F. Diaz, A. Perez-Martos, C. T. Moraes, P. Fernandez-Silva, A. Trifunovic, P. Navas, J. Vazquez and J. A. Enriquez (2016). "The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency." Cell Reports 15(1): 197-209.


Szczepanowska, K. and A. Trifunovic (2015). "Different faces of mitochondrial DNA mutators." Biochimica Et Biophysica Acta-Bioenergetics 1847(11): 1362-1372.


Rugarli, E. and A. Trifunovic (2015). "Is mitochondrial free radical theory of aging getting old?" Biochimica Et Biophysica Acta-Bioenergetics 1847(11): 1345-1346.


Papadopoulos, C., G. Orso, G. Mancuso, M. Herholz, S. Gumeni, N. Tadepalle, C. Jungst, A. Tzschichholz, A. Schauss, S. Honing, A. Trifunovic, A. Daga and E. I. Rugarli (2015). "Spastin Binds to Lipid Droplets and Affects Lipid Metabolism."Plos Genetics 11(4).


Belaidi, A. A., J. Roper, S. Arjune, S. Krizowski, A. Trifunovic and G. Schwarz (2015). "Oxygen reactivity of mammalian sulfite oxidase provides a concept for the treatment of sulfite oxidase deficiency." Biochemical Journal 469: 211-221.


Turpin, S. M., H. T. Nicholls, D. M. Willmes, A. Mourier, S. Brodesser, C. M. Wunderlich, J. Mauer, E. Xu, P. Hammerschmidt, H. S. Bronneke, A. Trifunovic, G. LoSasso, F. T. Wunderlich, J. W. Kornfeld, M. Bluher, M. Kroke and J. C. Bruing (2014). "Obesity-Induced CerS6-Dependent C-16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance." Cell Metabolism 20(4): 678-686.


Trifunovic, A. and N. Ventura (2014). "Mitochondria and metabolic control of the aging process." Experimental Gerontology 56: 1-2.


Li, L. S., A. Trifunovic, M. Kohler, Y. X. Wang, J. P. Berglund, C. Illies, L. Juntti-Berggren, N. G. Larsson and P. O. Berggren (2014). "Defects in beta-Cell Ca2+ Dynamics in Age-Induced Diabetes." Diabetes 63(12): 4100-4114.


Kukat, A., S. A. Dogan, D. Edgar, A. Mourier, C. Jacoby, P. Maiti, J. Mauer, C. Becker, K. Senft, R. Wibom, A. P. Kudin, K. Hultenby, U. Flogel, S. Rosenkranz, D. Ricquier, W. S. Kunz and A. Trifunovic (2014). "Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity." Plos Genetics 10(6).


Dogan, S. A., C. Pujol, P. Maiti, A. Kukat, S. Y. Wang, S. Hermans, K. Senft, R. Wibom, E. I. Rugarli and A. Trifunovic (2014). "Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart." Cell Metabolism 19(3): 458-469.


Coutelle, O., H. T. Hornig-Do, A. Witt, M. Andree, L. M. Schiffmann, M. Piekarek, K. Brinkmann, J. M. Seeger, M. Liwschitz, S. Miwa, M. Hallek, M. Kronke, A. Trifunovic, S. A. Eming, R. J. Wiesner, U. T. Hacker and H. Kashkar (2014). "Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing." Embo Molecular Medicine 6(5): 624-639.


Pujol, C., I. Bratic-Hench, M. Sumakovic, J. Hench, A. Mourier, L. Baumann, V. Pavlenko and A. Trifunovic (2013). "Succinate Dehydrogenase Upregulation Destabilize Complex I and Limits the Lifespan of gas-1 Mutant." Plos One 8(3).


Ahlqvist, K. J., R. H. Hamalainen, S. Yatsuga, M. Uutela, M. Terzioglu, A. Gotz, S. Forsstrom, P. Salven, A. Angers-Loustau, O. H. Kopra, H. Tyynismaa, N. G. Larsson, K. Wartiovaara, T. Prolla, A. Trifunovic and A. Suomalainen (2012). "Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice." Cell Metabolism 15(1): 100-109.


Kukat, A., D. Edgar, I. Bratic, P. Maiti and A. Trifunovic (2011). "Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts." Biochemical and Biophysical Research Communications 409(3): 394-399.


Hench, J., I. B. Hench, C. Pujol, S. Ipsen, S. Brodesser, A. Mourier, M. Tolnay, S. Frank and A. Trifunovic (2011). "A Tissue-Specific Approach to the Analysis of Metabolic Changes in Caenorhabditis elegans." Plos One 6(12).


Ross, J. M., J. Oberg, S. Brene, G. Coppotelli, M. Terzioglu, K. Pernold, M. Goiny, R. Sitnikov, J. Kehr, A. Trifunovic, N. G. Larsson, B. J. Hoffer and L. Olson (2010). "High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio." Proceedings of the National Academy of Sciences of the United States of America 107(46): 20087-20092.


Edgar, D., N. G. Larsson and A. Trifunovic (2010). "Point Mutations Are Causing Progeroid Phenotypes in the mtDNA Mutator Mouse." Cell Metabolism 11(1): 1-1.


Bruning, J., T. Langer and A. Trifunovic (2010). "Highlight: The Biology of Aging: Mechanisms and Intervention." Biological Chemistry 391(10): 1113-1113.


Bratic, I. and A. Trifunovic (2010). "Mitochondrial energy metabolism and ageing." Biochimica Et Biophysica Acta-Bioenergetics 1797(6-7): 961-967.


Bratic, I., J. Hench and A. Trifunovic (2010). "Caenorhabditis elegans as a model system for mtDNA replication defects." Methods 51(4): 437-443.


Edgar, D., I. Shabalina, Y. Camara, A. Wredenberg, M. A. Calvaruso, L. Nijtmans, J. Nedergaard, B. Cannon, N. G. Larsson and A. Trifunovic (2009). "Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice." Cell Metabolism 10(2): 131-138.


Bratic, I., J. Hench, J. Henriksson, A. Antebi, T. R. Burglin and A. Trifunovic (2009). "Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development." Nucleic Acids Research 37(6): 1817-1828.


Stewart, J. B., C. Freyer, J. L. Elson, A. Wredenberg, Z. Cansu, A. Trifunovic and N. G. Larsson (2008). "Strong purifying selection in transmission of mammalian mitochondrial DNA." Plos Biology 6(1): 63-71.