CECAD Microsite

Research topic

Main interest of our group is the role of mitochondrial (dys) function in the determination of longevity. Our research interest stems from the fact that mitochondrial DNA mutations and dysfunction accumulate with age. We are interested in understanding the molecular mechanisms and signalling pathways that are activated upon mitochondrial dysfunction during aging. We are working on two different model systems: transgenic mice models and the roundworm, Caenorhabditis elegans.

Lab-News

Sarah Maciej defends her PhD thesis

On 26 June 2020 Sarah Maciej successfully defended her PhD Thesis

New insights into ClpXP-mediated proteolysis

www.mcponline.org/content/early/2020/05/28/mcp.RA120.002082

Repair instead of renew in mammalian mitochondira

www.nature.com/articles/s41467-020-15467-7

Sophie Kaspar defends her PhD thesis

On 13 February 2020 Sophie Kaspar successfully defended her PhD Thesis

Eduard Hofsetz defends his PhD thesis

On 29 November 2019 Eduard Hofsetz successfully defended his PhD Thesis

Detox pathway extends lifespan of the worm C. elegans

https://www.nature.com/articles/s41467-019-11275-w

Metabolic alterations associated with CLPP-deficiency

www.embopress.org/doi/full/10.15252/embr.201745126